Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
The 43-year-old woman was placed on a 12-month good behaviour bond and banned from owning animals.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
萨默塞特?毛姆（Somerset Maugham）曾形容法国里维埃拉（French Rivier）为“阴暗人物的阳光之地”。环视着酒店大堂里的“模特”，带着黑超的男人们似乎与他们相识，我似乎理解了毛姆。戛纳华丽的外表下有着其并不光彩的一面，就如湛蓝的海水下垃圾成堆。电影节开幕前，法国潜水员，同时也是环保人士的Laurent Lombard(劳伦?隆巴德)拍摄的戛纳河床沉积着大量垃圾废物的视频被疯传。我们被告知在此游泳并无危险。据《每日邮报》报道，市长已下令清理。但是小镇确实不再那么闪耀迷人了。
不过，在长达四小时的马拉松般的颁奖典礼中，《月光男孩》所获奖项一度与《爱乐之城》并驾齐驱。巴里?詹金斯（Barry Jenkins，文首图中）和塔雷尔?阿尔文?麦克拉尼（Tarell Alvin McCraney，文首图右）获得了最佳改编剧本奖。马赫沙拉?阿里(Mahershala Ali)获得最佳男配角奖，这是美国穆斯林男演员首位获得奥斯卡奖。
Trends and targets in antiviral phototherapy
Ellen Johnson Sirleaf, 72, became Africa's first democratically elected female president in 2005. The Nobel Committee praised the Liberian leader for her efforts to secure peace, promote economic and social development and strengthen the position of women.
Charli XCX, 'Number 1 Angel'
Recent years have seen a return of the bacterial infection, reaching numbers not seen since the 1960s, with admissions for a primary diagnosis more than doubling between 2010/11 and 2017/18, from 429 to more than 1,300.
纽约人向专栏提出的问题，不仅取决于他们的个人情况，还取决于当今的重大问题，比如住房成本上升、士绅化、豆腐渣工程。最终，2014年成为了一个一切都在增长的年份，增长的包括房价、租金，以及最重要的——楼盘数量。根据纽约房地产委员会(Real Estate Board of New York)的数据，10月批准建设的单元达到了16700套。
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
'She does wear wigs and crowns and fancy dresses but I don't give her spray tans or cake her in makeup - I'll wait until she's about five for that.'
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Embrace the world
The spread of HIV through drug injections has been effectively controlled. In 2017, the number of people infected through drug abuse was 44.5 percent lower than that in 2012.
ACE2 as a potential therapeutic target for pandemic COVID-19
“New Yorkers have been waking up and realizing this long period of prosperity has wreaked a little bit of havoc on things that we think of as classic New York,” said Simeon Bankoff, the executive director of the Historic Districts Council, noting that 2015 will mark the 50th anniversary of the New York City landmarks preservation law. “Things we always thought were going to be there are just closing left and right.”
Diagnostic technologies for COVID-19: a review
Scientists confirmed Monday that a skeleton found under a carpark in the English city of Leicester was that of King Richard III, in a bizarre end to a 500-year-old historical mystery.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
10. A bad marriage can lead to an early death
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
专注于新兴市场的基金集团经历了难熬的一年，安本(Aberdeen)和安石(Ashmore)的资产管理规模都严重缩水。新兴市场交易所交易基金(ETF)也遭遇大规模赎回，ETF.com数据显示，投资者从贝莱德(BlackRock)旗下基金iShares MSCI Emerging Markets以及先锋(Vanguard)富时新兴市场(FTSE Emerging Markets)撤出95亿美元。
China’s tourism administration issued a notice on Friday confirming reports that Chinese travellers had been denied entry to South Korea’s Jeju island in recent months for holding incomplete travel documentation. It reminded citizens to “select travel destinations with caution”.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
As well as diversity, Mr Cook has championed sustainability and supply-chain transparency, including a commitment to reducing Apple’s use of conflict minerals. While hyper-efficient under Mr Cook’s management before he became chief executive, Apple’s supply chain has not always been something to boast about, with recurring complaints about working conditions.
James Gorman, a Times reporter, accompanied scientists who are trying to understand the genes that distinguish dogs from wolves. Humans who raise wolf puppies must spend 24 hours a day, seven days a week with them in order to socialize these puppies for scientific study. And while the pups may seem cute, they will grow to be predatory wolves, not humanity’s faithful companions. The researchers hope their work will help reveal the trigger that made some ancient wolves into the dogs we know today.
The letter surfaced in a Pennsylvanian university mailroom earlier this month.
The Microsoft founder's net worth is $86 billion, up from $75 billion last year.
Influenza neuraminidase: A druggable target for natural products
But, when the skeletal remains were analyzed, the researchers found that the tombs had been reused multiple times. Some of the tombs contain more than 10 occupants, and the"repeated multiple burials warrant further study," the researcherswrote.
“Climate change is perhaps the major challenge of our generation,” said Michael H. Freilich, director of earth sciences at NASA, one of the agencies that track global temperatures.
STEP 5: GET RID of most of your friends
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
We will make a big push for progress in the reform of the social system.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
2.The Fresh Prince of Bel Air was Almost Bankrupt
Sounds like Taylor Swift—but, in fact, it’s her frequent competitor, Katy Perry. Largely because of her Prismatic World Tour, which is now winding down, Perry pulled in $135 million this year. She grossed more than $2 million per city over the course of 126 shows in our scoring period, and added to her total through deals with Coty, Claire’s and Covergirl.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
伦敦博蒙特·内森顾问公司(Beaumont Nathan)的联合创始人雨果·内森(Hugo Nathan)说：“新投资者对早期绘画大师的作品有兴趣，不过他们想要的是杜维恩(Duveen)卖给强盗大亨们的作品。他们想要名作。”他指的是英国艺术交易商约瑟夫·杜维恩(Joseph Duveen)，他把很多伟大的艺术品带去了美国。
France, one of the most visited countries in the world, ranks No. 9 overall. It is No. 2 in Cultural Influence and No. 6 in Power.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
Trailing behind "Game of Thrones" on the most downloaded list are "Breaking Bad" and "The Walking Dead." Here is the list of 2013's most-downloaded TV shows (single episode) according to data collected by TorrentFreak and BitTorrent trackers:
The report shows Cases of dishonesty connected to e-commerce platforms and enterprises, logistics companies, third-party payment platforms and consumers in a five-day period from Nov 11 to 15 increased 57.49% compared to last year.
“When I started in this business, Brooklyn was the alternative. Now it is a choice,” said Diane M. Ramirez, the chief executive of Halstead Property. “I see Queens becoming that way. The Bronx is not that far down the line.”
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Unfortunately, there won't be a 2014 rematch between Brazil and Uruguay, as the latter was eliminated on Saturday. If Brazil makes it to the final on July 13, the country could play Mexico, the Netherlands, Costa Rica, Greece, USA, Belgium, Argentina or Switzerland.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
His strategic shift away from corporate strategy was in spite of the fact that his own school had deterred him from making a career in education, even though he had worked as a private tutor.
The second chart shows the real federal funds rate (ie discounting for inflation) and the real natural rate. Again, when the federal funds rate is above its natural rate, EM crises are more common.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Here are the 10 winners of the 2012 Ig Nobel Prizes given to scientists, writers, and peacemakers who make silly but thoughtful contributions to the world, or as the Annals of Improbable Research puts it, "first make people laugh, and then make them think." I can vouch for them making us laugh!
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
4. Add Color
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
The show was a potent reminder that the sexual revolution and women entering the work force and the rise of consumerism and the Age of Aquarius (all that) had a dark side, and claimed their own victims. That’s part of why it was such a powerful show.
We had everything before us, we had nothing before us…
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
The story of the year will be the New York City trial of Khalid Sheik Mohammed.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
勉强能。民主党需要再赢得24个席位，这意味着他们需要守住特朗普去年胜选的全部12个民主党选区，并拿下23个在大选中投票支持希拉里克林顿(Hillary Clinton)的共和党选区，另外再添上一两个选区。算起来形势对民主党不利，但从历史先例来看形势有利于民主党。历任总统所在的政党几乎总会在中期选举时丢掉一些众议院席位，有时丢得还挺多，特别是当在位总统的支持率低于50%的时候。看一看2010年的巴拉克奥巴马(Barack Obama)就知道了。
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Professor Ivarsflaten cited the U.K. Independence Party, whose official platform focused on Brexit but whose pitch to voters emphasized immigrants’ effects on the economy and culture, as an example of an effective hybrid populist pitch.
8. Employment futures weak as pensions drain states, municipalities
10. “Results” (Andrew Bujalski)
4. The 2012 Ig Nobel Neuroscience Prize
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
China's online game revenue in 2008 was CNY20.8 billion, accounting for about 27% global share, ahead of South Korea at 21% and slightly behind the U.S. at 29%, according to an earlier report by Shanghai-based market research firm iResearch. The firm also predicted that China is likely to surpass the U.S. to become the world's largest by the end of 2009.
Baby Driver recently placed on the National Board of Review’s Top 10 list. The film holds a 93% on Rotten Tomatoes and took in over $100 million dollars at the box office.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
It seems that Christmas time is here once again, and it is time again to bring in the New Year. We wish the merriest of Christmas to you and your loved ones, and we wish you happiness and prosperity in the year ahead.又该迎接新的一年了。我们向你及你的亲人们致以最美好的祝福，愿你在新的一年里事业兴旺，幸福美满！
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
If there are nine or 10 best picture nominees, it could grab a spot. Jordan Peele's screenplay looks certain to be recognized.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
NASA and the other American agency that maintains long-term temperature records, the National Oceanic and Atmospheric Administration, issued separate data compilations on Friday that confirmed the 2014 record. A Japanese agency had released preliminary information in early January showing 2014 as the warmest year.
The number of students who will study abroad after graduation has also seen a drop, down from 4.8 percent last year to 3.4 percent.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
This changed two years ago, though, when Tsinghua University broke into the top 20 for the first time, ranking 18th in 2016. Last year, Peking University joined it in the top 20.
CONTACT: Kathy Michalove, Seaboard Properties, (860) 535-8364; seaboardpropertiesre.com
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
The malaise was not confined to those picking individual stock winners. Through December 1, aggregate hedge fund returns trailed the market to the point of farce. According to data compiled by Bloomberg, hedge funds were up an average of 2% on the year, just barely offering the coupon rate of a risk-free 10-year Treasury note. Over 1,000 funds are on track to close down in 2014, the worst year for liquidations since 2009.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Two Chinese universities, University of Hong Kong and University of Macao, squeezed into the top 10 of the world's most international universities in 2016, according to a new list published by Times Higher Education on Thursday.
The prize sold for a winning bid of $950,000 at auction, and an additional buyer's commission brought the final sale price to $1.16 million.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
While Jaws's story is extremely unrealistic, it was based on a real series of deaths attributed to a single shark in 1916. In what has been dubbed the "most unique set of shark attacks that ever have occurred," the Jersey Shore saw four people die from shark bites over the course of two weeks. The offending shark was reportedly caught with body parts still in its digestive tract, although leading scientists still aren't sure what drove it to attack so many people.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Though bionic legs are of course a huge boon to amputees, they lack actual nerve connections with the body. As a result, walking on them is cumbersome and tiring. But last year, Seattle resident Zac Vawter was outfitted with the world's first thought-controlled leg, a bionic limb that takes signals directly from his mind.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
The Tsinghua-Insead EMBA programme, launched in 2007, entered the FT rankings with a bang in 2012, going straight into fourth place with its very first cohort. The programme has since been ranked second, third, and finally has achieved first place in the rankings this year.
A facile assay for rapid detection of COVID-19 antibodies
Whedon had always loved the seemingly separate ideas of sci-fi and westerns, and through The Killer Angels, he saw a way to combine them. "I wanted to play with that classic notion of the frontier," he said. "Not the people who made history, but the people history stepped on—the people for whom every act is the creation of civilization." And Whedon decided to set the frontier on a spaceship: a ship named Serenity.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Tiger got to hunt, bird got to fly;
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Peer review is an evaluation of work by one or more people of similar competence to those who produce the work, which helps validate research.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Celebritites always seem to have a better life than the rest of us;nicer house,cooler cars and even cuter children.Just look at these pictures of Shiloh Jolie-
Stand: Apple CEO Tim Cook fought for workplace protection for the LGBT community
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
'It's going to get volatile to the upside,' he said.
3. 《间谍之桥》(Bridge of Spies)。几年前，史蒂文·斯皮尔伯格(Steven Spielberg)进入了殿堂级导演的行列，从安德鲁·萨里斯(Andrew Sarris)所谓的“美国电影”中借鉴了最崇高的形式——这部影片中他仍然保持水准。
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
President Donald Trump is the nation's first billionaire president -- but he's not as rich as he used to be, according to the Forbes 2017 Billionaires List published last Monday.
She only learnt to walk five months ago, but 'Baby Beyoncé' is already strutting her stuff on stage at pageants.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
20. 对电影爱好者的最佳建议。8月学者韦勒·温斯顿·迪克森(Wheeler Winston Dixon)发出了警告：“如果你上亚马逊，看到什么精彩的黑白电影卖三美元，或者其他什么外国电影和鲜为人知的电影，赶快买下来，因为它就要绝版了，他们不会再出版它们了。”成千上万这种VHS格式的电影不会被做成DVD格式或蓝光格式，迪克森警告说。而下载的美丽新世界（又名电子销售）明年将是好年头。
Anti-HIV drug repurposing against SARS-CoV-2
China's 2016 office box sales are expected to exceed the 2015 total of 44 billion yuan (6.8 billion U.S. dollars), the country's film watchdog said.
The ranking of 95 schools, up from 90 last year, includes nine institutions, from seven countries, that were ranked for the first time. Frankfurt School of Finance and Management in 41st place is the year’s highest new entrant. The German school has one of the most gender-balanced programmes, with women accounting for 49 per cent of students.
Length-scale dependence of protein hydration-shell density
TV soaps regularly top the TV ratings but the highest trending show of 2012 was the BBC kids' show 'Mike The Knight' that beat US terror drama 'Homeland' and 'Towie.'
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Alumni from Edhec have the 11th highest average salary, at $105,000, behind the alumni from Sloan at $143,600. They also enjoyed theseventh-highest salary increase, at 79 per cent.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
4.Virtual Assistant: 17.6 percent increase
These concerns are real, but there are ways around them. For example, you can use your survival job to show employers that you're willing to work hard. And you can continue your job search after work.
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