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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

Meanwhile, producer prices were deflating at a rate of -5.9 per cent, a six-year low, for a third straight month.
From master story teller, Guillermo del Toro, The Shape of Water comes another worldly fairy tale for his audience, set against the backdrop of Cold War era America circa 1962. In the hidden high-security government laboratory where she works, lonely Elisa (Sally Hawkins) is trapped in a life of isolation. Elisa's life is changed forever when she and co-worker Zelda (Octavia Spencer) discover a secret classified experiment.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

又或者,今年是一群有跟虐待、性或其他有关的故事要讲的女性。她们其中几个人在我们的页面上分享了“我也是”(#MeToo)的经历。卡洛塔·加尔(Carlotta Gall)讲述了汉达·阿亚里(Henda Ayari)的故事。后者是一名拥有北非血统的法国公民,也是一名反萨拉菲派活动人士。她指控牛津大学某知名教授强奸了她。
对于购房者,也不都是坏消息:房价明年(2015年——译注)仍将上涨,但步伐可能会从飙涨趋于平缓。“房价不会一味地陡然上涨,”柯克兰集团(Corcoran)的首席执行官帕梅拉·利伯曼(Pamela Liebman)说,“买家都有点疲劳了。”

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

劳瑞斯蒂尔

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

这个节目围绕宾夕法尼亚州匹兹堡(Pittsburgh)的Abby Lee舞蹈学校里面的小孩子展开。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

上榜理由:食物、文化和恐怖故事
由于欧元危机的影响,希腊,意大利,葡萄牙以及西班牙的排名大幅下滑。然而下滑幅度最大的是由于近期的政治危机影响的埃及,缅甸,和沙特阿拉伯。
日前,斯坦福大学商学院(Stanford Graduate School of Business)教授彼得o库迪斯基于这场荷兰危机共同撰写了一篇文章,围绕“个人经验(而非市场信息)决定乐观、悲观以及信贷的获得与否”这种不那么科学的方法给出了现代经验。
乌拉圭之所以取得成功,不仅仅是因为它对足球的激情,还因为其早期文化的包容性。在1950年世界杯上,当时其邻国巴西仍然对黑人球员心存怀疑,乌拉圭队却以拥有一位黑人队长、杰出的巴雷拉而感到自豪。此外,乌拉圭在世界杯成型期的胜利造就了延续至今的血统,它的很多球员如今都在海外的一些世界豪门俱乐部踢球,如利物浦的苏亚雷斯和巴黎圣日耳曼的卡瓦尼。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

1号 what the fuck: “职场辣妈”的新境界
Beijing targets consumer prices inflation at 3.5 per cent, but weakening growth is keeping prices benign.
Yet disparities were clear among sectors and companies.
Fewer women than men have worked abroad for at least six months (42 per cent and 52 per cent respectively) but they share exactly the same motivations — to develop management skills, build their network and increase their earnings.

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

艾米卡兹明(Amy Kazmin)

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

赫洛维兹对爱尔兰广播公司RTE表示,他的新邦德形象强烈忠于50年代的邦德。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

这一新数据公布之际,杜特尔特正抵御国内外对其禁毒运动的指责,已有60万名潜在嫌疑人向当局自首。
据行业估计,到2020年,我国年度票房有望达到1000亿元人民币。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

capacity
A robust LinkedIn presence is crucial to any job search. You know that. Your manager knows that. And your manager probably knows that you know that – so she'll be concerned when you go from having a bare-bones profile on Monday to one jacked with additional work history, new connections, status updates and recommendations by Friday. "Don't go from zero to 500 overnight, because that can be quite obvious," Foss cautions。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

“As we work to keep and attract more young professionals and job creators, we appreciate every young person who is engaged and invested in our state.”
汉达·阿亚里(Henda Ayari)

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

2012年,电子烟开始流行,它们的工作原理是通过加热尼古丁的液体,模拟真实的烟。很多人认为电子烟是中国的制药商韩力发明的,他说梦到自己在烟雾缭绕的蒸气中快要窒息后,发明了电子烟。他的父亲死于吸烟引起的肺癌。他自己也是一个不折不扣的瘾君子,他曾尝试使用尼古丁贴片来戒烟,但失败了。
尽管詹姆斯和费德勒在工资和薪水上要少一些(相比于C罗和梅西),但是这两人去年的代言费是最高的,其中17次大满贯得主费德勒去年代言收入达到了4100万英镑。
bene好+fic做+ial表形容词,“有…的”→有好处的
PwC公司已为奥斯卡计票并准备获奖信封逾80年,这是奥斯卡历史上第一次出现颁奖时拿错信封的乌龙事件。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

在收入最高的大学毕业生中,科学和工程领域占据了主导地位,其中软件工程、生物科学和电子信息工程是最赚钱的专业。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

As the younger generation begins to frown on Bond’s chauvinistic attitudes and unhealthy lifestyle in the era of political correctness, Horowitz has introduced a cast of new characters who will point out the error of his ways.
伦敦商学院的MBA课程位列欧洲第一,与美国哥伦比亚商学院(Columbia Business School)合办的EMBA课程位列第三,管理硕士课程首次参与排名就跻身前10名。参与管理硕士课程排名是伦敦商学院夺得欧洲榜首的关键因素。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

201001/93725.shtmlNews trumpedcelebrities in 2010 as the BP oil spill in the Gulf of Mexico and World Cup soccer in South Africa topped the list of most-searched items of 2010, according to Yahoo!

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

授完奖,在他致谢他的粉丝和MTV之前,他兴奋地说到”首先,我想说我不确定我怎么能得到这个奖,因为我已经好几年没有出过唱片了,但是我得奖了。”另外,Kendrick Lamar获得了最佳录影带奖,尽管这位说唱歌手无法到场,而是他通过视频感谢了他的粉丝。

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
From the themed collection: 小区物管要谁干 业主一户一票选
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

祝老师新年充满平安和爱。
The base hopes to keep up public awareness of pandas and the necessity of conservation of their natural habitats while Increasing the wild population by reintroducing individuals into areas in China where populations have declined.
1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4:狂暴之路》(Mad Max: Fury Road),并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片,二者都应该到你能找到的最大的屏幕上去看。
他补充说道:“我很兴奋能有机会重返中国,并享受这个国家的文化以及把NBA现场比赛的激动直接带给中国球迷。”

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

他告诉记者说:“我认为,韩国对于美的定义很苛刻狭隘,因为我们是一个种族单一的国家,每个人看上去都差不多。整容也和自卑情绪有关。”
当然,影片中最惊人的一幕是外星人遇到一个涉世不深,外表因为多发性神经纤维瘤而丑陋的年轻男子,由亚当·皮尔森扮演。格雷泽带来的这一幕是全然无畏而且毫无感情波动的,或许这是从大卫·林奇的《象人》这部影片的主题变化而来。外星人并不会在本质上区分这位年轻男子的长相,但是她与这位男子相遇——两个外星人的遭遇?——触发了危机,使得她成为了猎物,而不是猎人。
动词last的现在分
Song “Happiness” (Mao A’Min)
爱你的老公!

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

At that time, the chief executive was also under pressure, given Apple’s lack of clear product direction beyond milking the iPhone. Sensing blood, activist investors began to circle the company; first David Einhorn, then Carl Icahn, have lobbied for changes to how Apple is run and manages its finances. Mr Icahn has pushed for Apple to raise huge debt to return up to $150bn to shareholders and urged it to release more products, including a television set.
Unlike several items on this list, artificial pancreas aren't still in some early development stage. The device very much exists and got FDA approval for sale this past September.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

单词scroll 联想记忆:

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
From the themed collection: 家具原创设计问题引发行业深思
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

据"可信证据"流行小天王Justin Bieber当爸爸了!

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 深圳:坚持不懈保障和改善民生
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

Zhaopin.com received 93,420 effective samples for the survey, which covered new grads completing higher vocational, undergraduate, master's or doctoral programs.
4.Venice, Italy
《二十二》讲述的是22名慰安妇的故事,是中国首部票房超过1亿元的纪录片。
Most of the cellphones sold in 2016 are smart phones installed with the Android system and 4G ready, according to the report.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

在令人失望的2014年里,基金投资者们没有太多的动作。总体而言,过去11个月中,主动选股基金仅新增了350亿美元资金,还不到2013年同期新增资金(1620亿美元)的四分之一。2013年是该行业自2007年以来首次实现资金净流入。不过,这并不是说基金行业毫无作为。截止感恩节,交易所交易基金(ETFs)和被动指数型基金吸纳了2060多亿美元净存款,行业领先者先锋集团管理的基金规模在今年夏末突破了3万亿美元大关。投资者们似乎已经决定,与其把宝押在“骑手”身上,不如直接把赌注押在“赛马”身上。
Traditionally Chinese universities scored less well in international ranking tables compared to US and European incumbents in levels of teaching and research.
Horowitz admitted that while doing so he has had to work carefully to preserve 007's characters and attitude as created by the spy novel’s first author Ian Fleming, who died in 1964.
高通(Qualcomm)总部所在地的农民们肯定像它的雇员一样超爱这家无线电公司。每周,高通会在其总部圣地亚哥择址两处举办农夫市集。出售的商品从传统农产品到果酱、果冻无所不包。凡是订购了“社区支持农业”素食礼盒的高通雇员,在总部的一家咖啡馆即可轻松收货。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

入围名单以聚焦科技业的图书为主,Basic Books和Oneworld Publications出版的《机器人的崛起:大规模失业的威胁与科技》最终战胜了强大的对手。
Christopher Nolan's World War II feature is probably just about the front runner for best film.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

王斌表示,去年母婴传播率也达到了历史最低点,从2012年的7.1%下降到2017年的4.9%。
Born to royalty in Burma, Olive Yang, who died on July 31, rejected her birthright to become a cross-dressing warlord and opium trafficker.
The world’s 100 biggest brands still command a significant premium over others and that value increased by 3 per cent to $3.4tn this year, according to the latest BrandZ rankings compiled by Millward Brown, the research agency.
"Sure, there are only whites in the stadium. It comes down to money," said Ana Beatriz Ferreira, a 27-year-old parking attendant in Rio de Janeiro, who is black. "Nobody I know could find affordable tickets."
举例来说,新浪微博就一直提供推特所不具备的一些功能,尤其是评论功能,让众多用户得以在别人发表的微博下发表自己的见解。拥有逾7亿用户的腾讯QQ即时信息服务也有众多附加功能,比如可以让用户改换形象的“皮肤”,同时QQ还是腾讯为其他产品和服务做广告的渠道。新浪拒绝置评。

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

The show was a potent reminder that the sexual revolution and women entering the work force and the rise of consumerism and the Age of Aquarius (all that) had a dark side, and claimed their own victims. That’s part of why it was such a powerful show.
在2014年开始的这轮放缓之前,中国的雇主对于奖金没有这么吝啬。奖金的数额会大大高于一个月的薪水,让回家度假的员工能拥有足以为长辈和其他家庭成员购买礼物(或存为积蓄)的现金。
这家Post-it即时贴和思高(Scotch)胶带制造商在2月份授权进行120亿美元的股票回购,取代当前75亿美元的回购计划。《财富》美国500强公司3M公司(3M) 遵循了去年末发表的声明行动。这项声明称,公司在之后4年准备投入100亿美元用于收购,最多将投入220亿美元用于回购。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

“You can choose to spend the time however you like,” he wrote, suggesting people “go travelling, pursue a philanthropic project, spend quality time with family or simply take time out to recharge and refocus”.
大多数专业顾问(包括我在内)都会对其客户大力鼓吹全球化多元投资组合的好处,然而,在12月看来,残酷的现实是2014年更像是个平局,而非大获全胜。事实上,上周摩根士丹利资本国际全球指数同比仅上涨了2%,而摩根士丹利资本新兴市场指数(MSCI Emerging Markets)和追踪美国以外发达国家市场的EAFE指数双双下跌了近5%。具有讽刺意味的是,除美国以外全球唯一一个表现上佳的市场——中国大陆股市的上证综指(上涨了45%),也是唯一一个美国投资者无法进入的市场。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
From the themed collection: 水泥漆和乳胶漆区别是啥?
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

Rafael Corrales, a partner at Charles River Ventures, believes that the growth in a wide range of fields—from academia to infrastructure to policy—is a sign that 2014 was the biggest year bitcoin has had yet, despite its volatility. “In the short-term, that’s an easy knock from people who don’t understand or believe it can be something,” he says. “It’s the easiest thing for them to go after. In that transition stage, you’re going to have extreme volatility, so looking at its value over one year is kind of silly.” As for occasional hacks, he adds, “There are going to be bumps in the short term, but they’ll be solved sooner than later. And these things are being addressed by a huge community of people. So you have to be really excited, despite small bumps.”
除了北方高等商学院和巴黎高等商学院以外,高等经济商业学院(Essec Business School)、巴黎高等商业学院-欧洲管理学院(ESCP Europe)和商科联盟国际商学院(Skema Business School)分列第三、第四和第六位。
CEOs: Newbies Mary Barra at GM and Mark Fields at Ford start playing close attention to the moves made by FCA’s Sergio Marchionne. Despite running his growing empire on two continents, Marchionne tacked on a U.S market share gain of 1.2 points, unhindered by one of the weakest product lineups in the business and troubles with his much heralded eight-speed transmission.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

But what about the tens of thousands of Irish fans? They're out of control.
Emily Ratajkowski managed to steal the show, opting for a seriously saucy twist on the classic ballgown. Opting for a semi-sheer lacey black number, the We Are Your Friends actress ensured her world-famous figure was on display.
In the near future, a weary Logan (Hugh Jackman) cares for an ailing Professor X (Patrick Stewart) at a remote outpost on the Mexican border. His plan to hide from the outside world gets upended when he meets a young mutant (Dafne Keen) who is very much like him. Logan must now protect the girl and battle the dark forces that want to capture her.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

"Metro-Goldwyn-Mayer Inc. ('MGM') today announced that the secured lenders voting in the Company's solicitation process have overwhelmingly approved its proposed plan of reorganization ('Plan'). MGM will now move expeditiously to implement that Plan, which will dramatically reduce its debt load and put the Company in a strong position to execute its business strategy. MGM is appreciative of the lenders' support."

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

9. The Chinese militarywill demand and receive vastly expanded investments in the form of advancedaircraft and ships.

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

1.《雨人》
像中国人口这么多的国家,关于寂寞的病毒式模仿会这么流行实在是件很讽刺的事情。这句看上去很无厘头的话被用在了所有可能搭配的排列中,用在了所有场合,比如,“哥看的不是书,是寂寞。”

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

6. The 2012 Ig Nobel Prize for Literature
The report also shows that despite the rising pension insurance balance since 2012, the payable number of months fell to 17.7 months last year from 19.7 months in 2012.
There are merely citizens whose choices not only may, but surely will, change.
Russia regards itself as a great power - it is not in question anywhere inside the country.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 居然之家发力“大家居”
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

n. 董事,经理,主管,指导者,导演
Trigger Mortis was released on September 8, ahead of the release of the latest Bond film Spectre which is out in cinemas on October 26.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
From the themed collection: 雷士照明要做全球前三的企业
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

These are the official James Bond theme songs, ranked from worst to best, with two honorable mentions because they may or may not count, but were just that good, dang it.
intelligence

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

The application window will close on Saturday, and successful candidates must pass the 2016 national civil service exam, which starts on Nov 29, before they're granted a job interview in March.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
From the themed collection: 建筑材料板块市场需求放大
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

['triti]
(G.I. Joe: Retaliation)以及两部小规模电影,加起来在全球的票房收入总计13亿美元。
中国企业家王兴(音)通过聊天软件“微信”(WeChat)与身在美国加州的姐姐和澳大利亚的叔叔保持联系。这款聊天软件让人得以一瞥中国网络公司怎样参与全球竞争。
There were multiple instances of the glamourous royalty keeping Canadians waiting, including the arrival, where the family took a whole 20 minutes to disembark in order to be greeted by the Canadian welcome party.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

The dollar value of outbound shipments from China rose 12.3 per cent year on year in November, lifting from a revised pace of 6.8 per cent in October, and smashing a median forecast of 5 per cent from economists polled by Reuters.
China (mainland and Hong Kong) adds 25 to the list this year, more than any other country, for a total of 207. Three countries debut on the list this year: Mauritius, Slovakia, and Togo.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

Landing a superstar like Cousins for pennies on the dollar won't singlehandedly help the Pelicans carve out a larger slice of the sports landscape in New Orleans, but it's an excellent first step.
More than 110 new and returning series made the shortlist for this roundup before being whittled down to the 20 that appear here. (And that’s without the HBO shows “True Detective,” which is being moved to later in the year, and “Game of Thrones,” “Veep” and “Silicon Valley,” whose April premiere dates haven’t been announced.) From a “Breaking Bad” spinoff, to the return of “Broadchurch,” to the final season of “Justified,” the winter is high season for the serious TV watcher.
[':tn]

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

In the season of joy I present my sincere wishes and kind thoughts. May the kind of New Year outshine all the rest.
鹈鹕一直在费力的吸引并留下自由球员,他们必须在这个夏天留下朱-霍勒迪,考辛斯的家乡在附近的阿拉巴马,而且他和安东尼-戴维斯是密友,同时,多个令人沮丧和伤病困扰的赛季让鹈鹕一直在失败的循环中摇摆。
乔斯·威登在度假的时候萌发了创作《萤火虫》的设想。他当时正在读一本叫做《天使杀手》的书,这本书讲述了一名葛底斯堡战役中的士兵的故事。威登深深地被这个士兵日复一日的艰辛生活所吸引。这本书的作者描写了大量日常生活中的繁琐细节,以及人们如何在缺乏现代科技和商业之便的情况下艰难度日。而威登对这种描写方式推崇备至。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

enterprise
On Her Majesty's Secret Service gets an honorable mention on our list of James Bond Theme songs.

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
From the themed collection: 北京购房市场回温 改善置业走俏
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
From the themed collection: 上海大力度支持民营经济提升活力
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

在这个风云变幻的世界,詹姆斯·邦德俘获了不少铁杆粉丝,是至今为数不多的仍在续拍的电影之一。在人们的意识里,无论发生什么事情,新的007电影依然会拍下去。
你如何知道你需要喝水了?这有一系列的诱因:嘴唇发干、头晕、头痛、尿量低和口渴。然而,这种智能瓶能在你的身体意识到缺水前就提醒你。
1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4:狂暴之路》(Mad Max: Fury Road),并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片,二者都应该到你能找到的最大的屏幕上去看。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

Actuaries put a financial value on risk for instance, the chances of a hurricane destroying a beachfront home or the long-term liabilities of a pension system. In a world awash with risks of the natural and manmade variety, the profession is booming, says Tony Lee, publisher of CareerCast.com. In addition, he says, 'there's a severe shortage of actuaries, ' so wages are rising. (The median salary for actuaries in 2010 was $87, 650, according to the Labor Department.)
The Big Tech backlash will spread to technology industry employees in 2018, as many question whether the work they do really is saving the world.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

出口复苏可能在一定程度上化解人们对于新兴市场国家的悲观看法。在本世纪初的那些年,许多新兴市场国家曾把出口强劲增长作为经济快速发展的跳板,后来出口由盛转衰了。
Yes, it is that obvious when you're interviewing elsewhere and go MIA, with or without a flimsy excuse. Schedule phone interviews for personal hours, like a lunch break, and take vacation or PTO days for lengthy in-person interviews. "That way, you're not feeling pressured during the interview to get back to work – which can affect how you handle the interview – and you're not stealing time from your employers," Kay says。
赢家:小牛

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

根据中国海关的数据,10月铁矿石进口量较上月环比下降12.3%,同比下降4.9%,而煤炭进口环比下降21.4%,同比下降30.7%。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

榜单的前20名中,除了排名第四的复旦大学和第六名的北京大学这两所综合类高校之外,其余席位多被财经类和理工类高校占据。
ICBC’s earnings per share were Rmb0.77, down from Rmb0.78 last year, and a pre-tax dividend per share was Rmb0.2333, down from Rmb0.2554.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

设计师布莱恩-卡朋特和布兰德-霍克因为酷爱户外运动而受到启发,决定想出一种创意方式,能够随处搭吊床。
10. 米歇尔?詹尼克(澳大利亚跨栏运动员)

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

Employees of state-owned firms also expressed more satisfaction with their bonuses than those at private companies – and little wonder, as the average payout at the former was Rmb17,318, or about Rmb6,000 more than what their private-sector counterparts could expect.
没有什么比老板所说和所做不一样更糟糕了,也没有什么比守信用更重要了。就像经理们一定要相信他们的团队,员工一定要相信他们的老板心中会为他们带来最佳利益。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

n. 枝,杆,手杖
《X战警:天启》据悉将于2016年5月27日上映。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Mr. Nathan was among the few dealers actively bidding at the evening sales. Buying on behalf of a client, he paid 506,500, or twice the estimate, at Christie’s for Charles-Antoine Coypel’s 1737 painting, “The Destruction of the Palace of Armida.”

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

Let’s never spend our New Year apart.让我们永不独享新年。
Comic skit “I Want To Be In Spring Festival Gala” (Various artistes)
当人们还在讨论政府执法机构迫使苹果公司解锁iPhone手机来寻找证据的行为是否合法,伦敦的Fone Fun商店却开始出售一种能破解iPhone四位锁屏密码的设备,售价仅170美元。
在可预见的未来,我国会见证第三产业的繁荣发展。该报告称,相关专业,包括法律、新闻传播和管理学,预计将扮演更重要的角色。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

4、《美国队长3:内战》

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Recipient: Britney Spears
ad+(mini小+ster→小人→古代大臣称自己是“小人”→部长,大臣)→做部长→管理,治理+ation→行政,管理
特约专栏作家安东尼·盖尔恩是Paragon欧洲合作伙伴的常务董事。目前位于伦敦。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

泰国董里岛——董里岛是泰国东南部一个可被雷达侦测到的沉睡之省,游人可以在那里租长尾船,到岛屿之间穿行,还可以去看濒临灭绝的儒艮。
We think of the passage of NBA time in seasons, for obvious reasons. There's connection, a continuum. It's how we remember things that happen, in the course of a season of play. But there's some benefit to looking back at a calendar year, January 1 to December 31, and what we've learned in that process. After all, many say the "unofficial start" to the NBA season is Christmas, with the new year starting soon after. So here are the lessons we learned about the NBA in the year 2017.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 商业地产是家居卖场的出路?
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

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Trigger Mortis was released on September 8, ahead of the release of the latest Bond film Spectre which is out in cinemas on October 26.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
From the themed collection: 人民时评:答好经济发展新考题
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

还记得《类人猿行动》吗.这是一部被众人忽略的2016年早些时候的电影,由杰米.多南和斯里安.墨菲担任主演,讲述了对希特勒身边的三把手、党卫队将军莱因哈德.海德里希进行的一次失败暗杀。《行动代号:猿人》也尝试讲述这一故事,杰克.莱诺和奥康奈尔将在片中饰演密谋的士兵,而罗莎曼德.派克和米娅.华希科沃斯卡是他们片中的感情对象,杰森.克拉科则饰演他们的刺杀目标。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Around 280 million train tickets have been sold on 12306.cn since Jan 3, 2018 when tickets for the Spring Festival holiday started selling.
The Hidrate Spark 2 tracks your water intake by syncing with a mobile app and recording how many ounces of water you drink a day, which can also be tracked by remembering how many times you refilled your bottle labeled with the number of ounces on the side.
hub

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

A network of walking and biking trails leads to other lakeside neighborhoods and to downtown, which is about 15 minutes by bicycle and 10 by car. The Walker Art Center and other museums are nearby. Hockey and skating are popular on the lakes in winter; canoeing, swimming and fishing in the summer.
Lady Gaga ranks fourth with $59 million, followed by Beyoncé at $54.5 million. The former played 66 shows during our scoring period, also cashing in on deals with Versace and MAC, as well as her own Fame fragrance. The latter’s On The Run tour with husband Jay Z grossed over $100 million for 19 North American dates, giving music’s first couple a nightly average comparable to that of the Rolling Stones.
We learned that animals may make choices based on aesthetics.
伯利兹城最富盛名的旅游胜地莫过于巨大的水下天坑--蓝色巨洞以及玛雅遗址。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

不像那些狂热追星的小女孩,玛蒂认为她一直都能保持着冷静的头脑,即使在格莱美颁奖典礼这种场合。因为她将自己视为一个明星,所以她需要表现得体。
Tom Petty

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Those in third-tier cities are under relatively low financial stress and human relations stress, and enjoy better social and natural environments, and infrastructure.
2014届大学毕业生工作半年后,平均月收入为3487元,较2013届的3250元、2012届的3048元有了较大增长。
报告指出,他们的家庭平均每月大约会收到200美元,这占到了他们家庭收入的60%。使用这笔稳定的汇款,他们的家人可以解决吃饭、住房、上学、医疗问题,改善卫生条件,进行一些投资,或者有一定的存款。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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